Peng Lab 
Chromatin Structure and Epigenetic Dynamics in Live Cells


Peng Q.*, †, Huang Z. *, Sun K., Liu Y., Yoon C., Harrison R., Schmitt D., Zhu L., Wu Y., Tasan I., Zhao H., Zhang J., Zhong S., Wang Y. Engineering Inducible Biomolecular Assemblies for Genome Imaging and Manipulation in Living Cells. Nat Commun, 2022, 13, 7933. († Corresponding author)

Nature Communications.

Liu J., Wang J., Liu Y., Xie S., Zhang J., Zhao C., Zhou Y., Pang W., Yao W., Peng Q., Wang X., Zhou J. LLPS of DDR1 counteracts the Hippo pathway to orchestrate arterial stiffening. Circ Res. 2022. doi: 10.1161/CIRCRESAHA.122.322113.

Circulation Research.

Song Y., Soto J., Chen B., Hoffman T., Zhao W., Zhu N., Peng Q., Liu L., Ly C., Wong P.K., Wang Y., Rowat A., Kurdistani S., and Li S. Transient nuclear deformation primes epigenetic state and promotes cell reprogramming, Nature Materials, 2022, 21, 1191-1199.

Nature Materials.

Qu K, Wang C, Huang L, Qin X, Zhang K, Zhong Y, Ma Q, Yan W, Li T, Peng Q., Wang Y, Gregersen H, Tang C, Qiu J, Wang G. TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis. Int J Biol Sci. 2022 Feb 28;18(5):2163-2180. 

International Journal of Biological sciences.

Liu H., Liu Y., Wang H., Zhao Q., Zhang T., Xie S., Liu Y., Tang Y., Peng Q., Pang W., Yao W., Zhou J. Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation. Adv Sci (Weinh). 2022, e2203995. 

Advanced Science.

Liu S., Li P., Sha H., Dong J., Huang Y., Zhao Y., Yao X., Peng Q., Li X., Lin X., Zhang Y. Intensity and phase imaging through scattering media via deep despeckle complex neural networks. Opt. Laser. Eng. 2022, 159: 107196. 

Optics and Lasers in Engineering.


Peng Q, Weng K , Li S , et al. A Perspective of Epigenetic Regulation in Radiotherapy[J]. Frontiers in Cell and Developmental Biology, 2021, 9.

Frontiers in Cell and Developmental Biology.

MAEM. S., Safitri M., Zhou T., Wang L., McGinty S., Zhang H., Yin Y., Peng Q., Qiu J.,Wang G. Unexpected Role of Nonimmune Cells: Amateur Phagocytes[J]. DNA and Cell Biology, 2021.

DNA and Cell Biology.

Harrison RES, Weng K, Wang Y, Peng Q. Phase Separation and Histone Epigenetics in Genome Regulation. Curr Opin Solid State Mater Sci, 2021, 25(1): 100892

Current Opinion in Solid State and Materials Science.

Xin K F, Jiang S W, Chen X, He Y H , Zhang J, Wang H P,  Liu H H, Peng Q, et al. Low-cost whole slide imaging system with single-shot autofocusing based on color-multiplexed illumination and deep learning[J]. Biomedical Optics Express2021, 12(9): 5644-5657.

Biomedical Optics Express

Xie G Y, Wu X N, Ling Y Y, Rui Y L, Wu D Y, Zhou J W, Li J X, Lin S B, Peng Qet al. A novel inhibitor of N 6 -methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities[J]. Acta Pharmaceutica Sinica B, 2021.

Acta Pharmaceutica Sinica B

Gong Y., Wei C., Cheng L., Ma F., Lu S., Peng Q., Liu L. and Wang Y. Tracking the Dynamic Histone Methylation of H3K27 in Live Cancer Cells, ACS Sensors, 2021, 6(12):4369-4378

ACS Sensors


Ziliang Huang, Mingxing Ouyang, Shaoying Lu, Yingxiao Wang, Peng Q, Optogenetic Control for Investigating Subcellular Localization of Fyn Kinase Activity in Single Live Cells, Journal of Molecular Biology, 2020, 432(7):1901-1909.

Journal of Molecular Biology

Li S , Yang D , Gao L , Y Wang,Peng Q. Epigenetic regulation and mechanobiology[J]. Biophysics Reports, 2020(2).

Biophysics Reports

Yang J, Zhao Z, Du C, Wang W, Peng Q, Qiu J, Wang G. The realization of robotic neurorehabilitation in clinical: use of computational intelligence and future prospects analysis[J]. Expert Review of Medical Devices, 2020, 17(4):1-12.

Expert Review of Medical Devices

Dutta P., Zhang L., Zhang H., Peng Q. Unphosphorylated STAT3 in heterochromatin formation and tumor suppression in lung cancer[J]. BMC Cancer, 2020, 20(1).

BMC Cancer


Ouyang M., Wan R., Qin Q., Peng Q., et al.  Sensitive FRET biosensor reveals Fyn kinase regulation by sub-membrane localization.[J]. ACS Sensors, 2019.

ACS Sensors

Wan R., Wu J., Ouyang M., Lei L., Wei J., Peng Q., et al. Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor[J]. Science advances, 2019, 5(6):eaau2001.

Science Advances


Peng Q, Lu S, Shi Y, et al. Coordinated histone modifications and chromatin reorganization in a single cell revealed by FRET biosensors[J]. Proceedings of the National Academy of Sciences, 2018, 115(50):201811818.

      Limsakul P, Peng Q, Wu Y, et al. Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface[J]. Cell Chem Biol, 2018: S2451945618300023.

      Cell Chemical Biology

      Hard R, Li N , He W, Ross B., Mo GCH., Peng Q., et al. Deciphering and engineering chromodomain-methyllysine peptide recognition[J]. Science Advances, 2018, 4(11).

      Science Advances

      Pengzhi W, Jing L, Shi L Z, Y Wang,Z Ping,M Ouyang,P Daryl,Peng Q, et al. Visualizing spatiotemporal dynamics of intercellular mechanotransmission upon wounding[J]. ACS Photonics, 2018:acsphotonics.8b00383.


Yoon S, Wang P, Peng Q, et al. Acoustic-transfection for genomic manipulation of single-cells using high frequency ultrasound[J]. Scientific Reports, 2017, 7(1):5275.


Liao X, Lu S, Wu Y, Xu W., Zhuo Y., Peng Q., et al. The Effect of Differentiation Induction on FAK and Src Activity in Live HMSCs Visualized by FRET[J]. Plos One, 2013, 8.

Plos One


Peng Q, Qiu J, Sun J, et al. The nuclear localization of MGF receptor in osteoblasts under mechanical stimulation[J]. Molecular & Cellular Biochemistry, 2012, 369(1-2):147-156.

Molecular & Cellular Biochemistry

Qiu J, Peng Q, Zheng Y, et al. OxLDL stimulates Id1 nucleocytoplasmic shuttling in endothelial cell angiogenesis via PI3K Pathway[J]. BBA - Molecular and Cell Biology of Lipids, 2012, 1821(10):1361-1369.

BBA - Molecular and Cell Biology of Lipids

Xin C, Bingbing Z, Yuanliang W, C Xian,L Yang,M Deng,Peng Q,Y Li. Mechano-growth factor E peptide inhibits the differentiation and mineralization of osteoblasts[J]. Archives of Oral Biology, 2012, 57(6):720-727.

Archives of Oral Biology


Peng Q, Wang Y , Qiu J , et al. A novel mechanical loading model for studying the distributions of strain and mechano-growth factor expression[J]. Archives of Biochemistry & Biophysics, 2011, 511(1-2):8-13.

Archives of Biochemistry & Biophysics

Qiu J , Wang G , Zheng Y , J Hu,Peng Q,T Yin. Coordination of Id1 and p53 Activation by Oxidized LDL Regulates Endothelial Cell Proliferation and Migration[J]. Annals of Biomedical Engineering, 2011, 39(12):2869-78.

Annals of Biomedical Engineering

Qiu J., Wang G., Peng Q., et al. Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling[J]. International Journal of Molecular Medicine, 2011.

International Journal of Molecular Medicine

Qiu J , Wang G , Hu J , Peng Q,Y Zheng. ID1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin[J]. Molecular and Cellular Biochemistry, 2011, 357(1-2):125-133.

Molecular and Cellular Biochemistry