Peng Lab 
Decoding Epigenetics and Nuclear Mechanics in Living Cells

PUBLICATIONS
2024

[37] Zhao Y, Yang MQ, Gong FL, Pan YQ, Hu MH, Peng Q, Lu LN, Lyu XW, Sun K. Accelerating 3D genomics data analysis with Microcket. Communications Biology, 7, 675 (2024). 

Communications Biology.



[36] Gao KX, Xie YF, Xu FN, Peng Q, Fu L, Wang GX, Qiu Jh. Silk fibroin promotes H3K9me3 expression and chromatin reorganization to regulate endothelial cell proliferation. APL Bioeng, 8, 026115. 

APL Bioengineering.


[35] Zhu LS, Man CW, Harrison RE.S., Wu ZH, Limsakul P, Peng Q, Hashimoto M, Mamaril AP., Xu HQ, Liu LW, Wang YX. Engineering a Programmed Death-Ligand 1-Targeting Monobody Via Directed Evolution for SynNotch-Gated Cell Therapy. ACS NANO, 2024. 

ACS NANO.


[34] Zhou JW, Zhang HS, Zhong K, Tao LJ, Lin Y, Xie GY, Tan YH, Wu Y, Lu YQ, Chen ZJ, Li JX, Deng X, Peng Q, Li ZG, Wang HS. N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA. National Science Review, 2024, nwae039. 

National Science Review.


2023

[33] Chen YW, Huang ZL, Peng Q*, Wang YX*. Single genomic loci labeling and manipulation using SIMBA system. Current Protocols, 2023, 3, e947. 

Current Protocols.


[32] Sun LJ, Zuo ZY, Qiu XK, Wang GX, Li QQ, Qiu JH, Peng Q. Recent advances in the interplay between stress granules and m6A RNA modification. Current Opinion in Solid State and Materials Science. 2023, 27(6):101119.

Current Opinion in Solid State and Materials Science.


[31] Liu J, Wang J, Liu Y, Xie SA, Zhang J, Zhao C, Zhou Y, Pang W, Yao W, Peng Q, Wang X, Zhou J. LLPS of DDR1 counteracts the Hippo pathway to orchestrate arterial stiffening. Circ Res. 2023, 32:87-105.

Circulation Research.



2022

[30] Peng Q^*, Huang Z^, Sun K, Liu Y, Yoon CW, Harrison RES, Schmitt DL, Zhu L, Wu Y, Tasan I, Zhao H, Zhang J, Zhong S, Chien S, Wang Y*. Engineering Inducible Biomolecular Assemblies for Genome Imaging and Manipulation in Living Cells. Nat Commun, 2022, 13(1):7933. (*Corresponding author)

Nature Communications.


[29] Song Y, Soto J, Chen B, Hoffman T, Zhao W, Zhu N, Peng Q, Liu L, Ly C, Wong PK, Wang Y, Rowat AC, Kurdistani SK, Li S. Transient nuclear deformation primes epigenetic state and promotes cell reprogramming. Nature Materials. 2022, 21(10):1191-1199.

Nature Materials.


[28] Qu K, Wang C, Huang L, Qin X, Zhang K, Zhong Y, Ma Q, Yan W, Li T, Peng Q, Wang Y, Gregersen H, Tang C, Qiu J, Wang G. TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis. Int J Biol Sci. 2022, 18(5):2163-2180. 

International Journal of Biological sciences.


[27] Liu H, Liu Y, Wang H, Zhao Q, Zhang T, Xie SA, Liu Y, Tang Y, Peng Q, Pang W, Yao W, Zhou J. Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation. Adv Sci (Weinh). 2022, 9(32):e2203995.

Advanced Science.


[26] Liu S, Li PSha HDong JHuang YZhao YYao XZou WChen Y, Wang MPeng QLi XLin X, Zhang Y. Intensity and phase imaging through scattering media via deep despeckle complex neural networks. Opt Laser Eng. 2022, 159:107196. 

Optics and Lasers in Engineering.


[25] Xie G, Wu XN, Ling Y, Rui Y, Wu D, Zhou J, Li J, Lin S, Peng Q, Li Z, Wang H, Luo HB. A novel inhibitor of N 6 -methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities. Acta Pharmaceutica Sinica B, 2022, 12(2):853-866.

Acta Pharmaceutica Sinica B

2021

[24] Peng Q^*, Weng KG^, Li ST^, Xu R, Wang YX, Wu YZ*. A Perspective of Epigenetic Regulation in Radiotherapy. Frontiers in Cell and Developmental Biology, 2021, 9:624312.

Frontiers in Cell and Developmental Biology.


[23] Sihombing MAEM, Safitri M, Zhou T, Wang L, McGinty S, Zhang HJ, Yin Y, Peng Q, Qiu J, Wang G. Unexpected Role of Nonimmune Cells: Amateur Phagocytes. DNA and Cell Biology, 2021, 40(2):157-171.

DNA and Cell Biology.


[22] Harrison R E, Weng KG, Wang YX*, Peng Q*. Phase Separation and Histone Epigenetics in Genome Regulation. Curr Opin Solid State Mater Sci, 2021, 25(1):100892.

Current Opinion in Solid State and Materials Science.


[21] Xin K, Jiang S, Chen X, He Y, Zhang J, Wang H, Liu H, Peng Q, Zhang Y, Ji X. Low-cost whole slide imaging system with single-shot autofocusing based on color-multiplexed illumination and deep learning. Biomedical Optics Express2021, 12(9):5644-5657.

Biomedical Optics Express


[20] Gong Y, Wei C, Cheng L, Ma F, Lu S, Peng Q, Liu L, Wang Y. Tracking the Dynamic Histone Methylation of H3K27 in Live Cancer Cells. ACS Sensors, 2021, 6(12):4369-4378.

ACS Sensors


2020

[19] Huang ZL, Ouyang MX, Lu SY, Wang YX*, Peng Q*. Optogenetic Control for Investigating Subcellular Localization of Fyn Kinase Activity in Single Live Cells. Journal of Molecular Biology, 2020, 432(7):1901-1909.

Journal of Molecular Biology


[18] Li ST, Yang DY, Gao L , Wang YX*Peng Q*. Epigenetic regulation and mechanobiology. Biophysics Reports, 2020, 6, 33-48.

Biophysics Reports


[17] Yang JL, Zhao ZQ, Du CZ, Wang W, Peng Q, Qiu J, Wang G. The realization of robotic neurorehabilitation in clinical: use of computational intelligence and future prospects analysis. Expert Review of Medical Devices, 2020, 17(4):1-12.

Expert Review of Medical Devices


[16] Dutta P, Zhang L, Zhang H, Peng Q, Montgrain PR, Wang Y, Song Y, Li J, Li WX. Unphosphorylated STAT3 in heterochromatin formation and tumor suppression in lung cancer. BMC Cancer, 2020, 20(1):145. 

BMC Cancer

2019

[15] Ouyang MX, Wan RX, Qin Q, Peng Q, Wang PZ, Wu J, Allen M, Shi YW, Laub S, Deng LH, Lu SY, Wang YX.  Sensitive FRET biosensor reveals Fyn kinase regulation by sub-membrane localization. ACS Sensors, 2019, 4(1):76-86.

ACS Sensors


[14] Wan RX, Wu J, Ouyang MX, Lei L, Wei JM, Peng Q, Harrison R, Wu YQ, Cheng BB, Li KT, Zhu C, Tang LL, Wang YX, Lu SY. Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor. Science advances, 2019, 5(6):eaau2001.

Science Advances

2018

[13] Peng Q, Lu S, Shi Y, Pan Y, Limsakul P, Chernov AV, Qiu J, Chai X, Shi Y, Wang P, Ji Y, Li YJ, Strongin AY, Verkhusha VV, Izpisua Belmonte JC, Ren B, Wang Y, Chien S, Wang Y. Coordinated histone modifications and chromatin reorganization in a single cell revealed by FRET biosensors. Proceedings of the National Academy of Sciences, 2018, 115(50):201811818.


      [12] Limsakul P, Peng Q, Wu Y, Allen ME, Liang J, Remacle AG, Lopez T, Ge X, Kay BK, Zhao H, Strongin AY, Yang XL, Lu S, Wang Y. Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface. Cell Chem Biol, 2018, 25(4):370-379.e4.

      Cell Chemical Biology


      [11] Hard R, Li N, He W, Ross B, Mo GCH, Peng Q, Stein RSL, Komives E, Wang Y, Zhang J, Wang W. Deciphering and engineering chromodomain-methyllysine peptide recognition. Science Advances, 2018, 4(11):eaau1447.

      Science Advances


      [10] Wang P, Liang J, Shi LZ, Wang Y, Zhang P, Ouyang M, Preece D, Peng Q, Shao L, Fan J, Sun J, Li SS, Berns MW, Zhao H, Wang Y. Visualizing spatiotemporal dynamics of intercellular mechanotransmission upon wounding. ACS Photonics, 2018, 5(9):3565-3574.

2017

[9] Yoon S, Wang P, Peng Q, Wang Y, Shung KK. Acoustic-transfection for genomic manipulation of single-cells using high frequency ultrasound. Scientific Reports, 2017, 7(1):5275.

2013

[8] Liao X, Lu S, Wu Y, Xu W, Zhuo Y, Peng Q, Li B, Zhang L, Wang Y. The Effect of Differentiation Induction on FAK and Src Activity in Live HMSCs Visualized by FRET. Plos One, 2013, 8(8):e72233.

Plos One

2012

[7] Peng Q, Qiu J, Sun J, Yang L, Zhang B, Wang Y. The nuclear localization of MGF receptor in osteoblasts under mechanical stimulation. Molecular & Cellular Biochemistry, 2012, 369(1-2):147-156.

Molecular & Cellular Biochemistry


[6] Qiu J, Peng Q, Zheng Y, Hu J, Luo X, Teng Y, Jiang T, Yin T, Tang C, Wang G. OxLDL stimulates Id1 nucleocytoplasmic shuttling in endothelial cell angiogenesis via PI3K Pathway. BBA - Molecular and Cell Biology of Lipids, 2012, 1821(10):1361-1369.

BBA - Molecular and Cell Biology of Lipids


[5] Xin C, Bingbing Z, Yuanliang W, C Xian,L Yang,M Deng,Peng Q,Y Li. Mechano-growth factor E peptide inhibits the differentiation and mineralization of osteoblasts. Archives of Oral Biology, 2012, 57(6):720-727.

Archives of Oral Biology

2011

[4] Peng Q, Wang Y, Qiu J, Zhang B, Sun J, Lv Y, Yang L. A novel mechanical loading model for studying the distributions of strain and mechano-growth factor expression. Archives of Biochemistry & Biophysics, 2011, 511(1-2):8-13.

Archives of Biochemistry & Biophysics


[3] Qiu J , Wang G , Zheng Y , J Hu,Peng Q,T Yin. Coordination of Id1 and p53 Activation by Oxidized LDL Regulates Endothelial Cell Proliferation and Migration. Annals of Biomedical Engineering, 2011, 39(12):2869-78.

Annals of Biomedical Engineering


[2] Qiu J, Wang G, Peng Q, Hu J, Luo X, Zheng Y, Teng Y and Tang C. Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling. International Journal of Molecular Medicine, 2011, 28(4):543-8.

International Journal of Molecular Medicine


[1] Qiu J , Wang G , Hu J , Peng Q,Y Zheng. ID1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin. Molecular and Cellular Biochemistry, 2011, 357(1-2):125-133.

Molecular and Cellular Biochemistry