Qianqian Li

liqq@szbl.ac.cn

EDUCATION

2010-2014 B.S. Department of Chemistry

2014-2019 PhD Department of Chemistry

2019-2021 Postdoc

2021-present Assistant Researcher

Tsinghua University, China

School of Pharmaceutics (Shenzhen), Sun Yat-sen University, China

Shenzhen Bay Laboratory, China

AWARD

2017-2018 Excellent Poster Award of the 11th National Symposium on Phosphorus Chemistry and Chemical Engineering; Excellent Oral Report Award of the 2nd Beijing-Tianjin Organic Chemistry Graduate Academic Exchange Conference; Comprehensive Scholarship of Tsinghua University

2015-2016 Outstanding Poster Award of the 14th China International Polypeptide Society; Tang Lixin Outstanding Counselor Award of Tsinghua University

2013-2014 Comprehensive Second-class Scholarship of Tsinghua University

2012-2013 Academic excellence scholarship AND outstanding Communist Youth League member of Tsinghua University

FUNDING

[1] Youth program of National Natural Science Foundation of China, 2021-2014, Host

[2] Special Program for Chinese postdoctoral fellows (before Station), 2019-2021, Host

PUBLICATION

[1] Qian-Qian Li; Ting-Ting Chu; Yong-Xiang Chen; Yan-Mei Li*, Tau Protein Associated Inhibitors in Alzheimer Disease. Chinese Journal of Chemistry 2014, 32 (10), 964-968.

[2] T. T. Chu; Q. Q. Li; T. Qiu; Z. Y. Sun; Z. W. Hu; Y. X. Chen; Y. F. Zhao; Y. M. Li*, Clearance of the intracellular high level of the tau protein directed by an artificial synthetic hydrolase. Mol Biosyst 2014, 10 (12), 3081-5.

[3] T. T. Chu; N. Gao; Q. Q. Li; P. G. Chen; X. F. Yang; Y. X. Chen; Y. F. Zhao; Y. M. Li*, Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation. Cell Chemical Biology 2016, 23 (4), 453-461.

[4] Na Gao; Ting-Ting Chu; Qian-Qian Li; Yeh-Jun Lim; Tian Qiu; Meng-Rong Ma; Zhi-Wen Hu; Xi-Fei Yang; Yong-Xiang Chen; Yu-Fen Zhao; Yan-Mei Li*, Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau. Rsc Adv 2017, 7 (64), 40362-40366

[5] Q. Q. Li; P. G. Chen; Z. W. Hu; Y. Cao; L. X. Chen; Y. X. Chen; Y. F. Zhao; Y. M. Li*, Selective inhibition of cancer cells by enzyme-induced gain of function of phosphorylated melittin analogues. Chem Sci 2017, 8 (11), 7675-7681.

[6] Pu-Guang Chen; Zhi-Hua Huang; Zhan-Yi Sun; Qian-Qian Li; Yong-Xiang Chen; Yu-Fen Zhao, Yan-Mei Li*; Synthesis of an MUC1 Glycopeptide Dendrimer Based on β-Cyclodextrin by Click Chemistry. Synlett 2017, 28 (15), 1961-1965.

[7] H. Chen; Y. Zhang; Q. Q. Li; Y. F. Zhao; Y. X. Chen; Y. M. Li*, De Novo Design To Synthesize Lanthipeptides Involving Cascade Cysteine Reactions: SapB Synthesis as an Example. J Org Chem 2018, 83 (14), 7528-7533.

[8] J. J. Wu; W. H. Li; P. G. Chen; B. D. Zhang; H. G. Hu; Q. Q. Li; L. Zhao; Y. X. Chen; Y. F. Zhao; Y. M. Li*, Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines. Chemical communications 2018, 54 (69), 9655-9658.

[9] Q. Q. Li; Y. Q. Liu; Y. Y. Luo; T. T. Chu; N. Gao; P. G. Chen; Y. X. Chen; Y. M. Li*, Uncovering the pathological functions of Ser404 phosphorylation by semisynthesis of a phosphorylated TDP-43 prion-like domain. Chemical communications 2020, 56 (40), 5370-5373.

[10] Z. Q. Shi; Q. Q. Li; L. Mei*, pH-Sensitive nanoscale materials as robust drug delivery systems for cancer therapy. Chinese Chem Lett 2020, 31 (6), 1345-1356.

[11] F. Zhang; G. H. Lu; X. L. Wen; F. Li; X. Y. Ji; Q. Q. Li; M. Y. Wu; Q. Z. Cheng; Y. K. Yu; J. Tang; L. Mei*, Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy. J Control Release 2020, 326, 131-139.

[12] Qianqian Li; Zhaoqing Shi; Fan Zhang; Weiwei Zeng; Dunwan Zhu*; Lin Mei*, Symphony of nanomaterials and immunotherapy based on the cancer‒immunity cycle. Acta Pharmaceutica Sinica B 2021. DOI: 10.1016/j.apsb.2021.05.031

[13] C. Q. Liang; L. Wang; Y. Y. Luo; Q. Q. Li; Y. M. Li*, Capturing protein droplets: label-free visualization and detection of protein liquid-liquid phase separation with an aggregation-induced emission fluorogen. Chemical communications 2021, 57 (31), 3805-3808.

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