Peng Lab 
Decoding Epigenetics and Nuclear Mechanics in Living Cells

​​​​​​​Qin Peng

pengqin@szbl.ac.cn

+0755-26849223

EDUCATION


2006 - 2010    B.S. Bioengineering 

2010 - 2015    Ph.D. Biomedical Engineering

2012 - 2013    Joint Ph.D program in Bioengineering

2013 - 2015    Joint Ph.D program in Bioengineering

2015 - 2017     Postdoctoral Researcher 

2017 - 2020     Assistant Project Scientist 

2020 - present   Tenure-track Assistant Professor



Chongqing University, China

Chongqing University, P. R. China

University of Illinois at Urbana-Champaign, USA

University of California at San Diego, USA

University of California at San Diego, USA

University of California at San Diego, USA

Shenzhen Bay Laboratory, China

AWARD


2016             UCSD Postdoc Travel Award

2012-2014    National Public-sponsored Joint Training Scholarship

2010             Excellent Graduation Project of Chongqing University

2009             Huang Ganheng Foundation Scholarship

2008             Excellent Student of Chongqing University


PUBLICATION

 

[1] Peng Q.#, Weng K., Li S., Xu R., Wang Y., Wu Y. A Perspective of Epigenetic Regulation in Radiotherapy. Front Cell Dev Biol. 2021, 9(624312). DOI: 10.3389/fcell.2021.624312.#Corresponding author. 

 

[2] Peng Q., Lu S., Shi Y., Pan Y., Limsakul P., Chernov AV., Qiu J., Chai X., Shi Y., Wang P., Ji Y., Li YJ., Strongin AY., Verkhusha VV., Izpisua Belmonte JC., Ren B., Wang Y., Chien S., Wang Y. Coordinated Histone Modifications and Chromatin Reorganization in a Single Cell Revealed by FRET Biosensors. Proc Natl Acad Sci U S A. 2018, 115(50): E11681-E11690. DOI: 10.1073/pnas. 

 

[3] Limsakul P. *, Peng Q.*, Wu Y., Allen ME., Liang J., Remacle AG., Lopez T., Ge X., Kay BK., Zhao H., Strongin AY., Yang XL., Lu S., Wang Y. Directed Evolution to Engineer Monobody for FRET Biosensor Assembly at Live-Cell Surface. Cell Chem Biol. 2018, 25(4): 370-379.e4. DOI: 10.1016/j.chembiol.2018.01.002. * co-first author. 

 

[4], Harrison R., Weng K., Wang Y.#Peng Q.#. Phase Separation and Histone Epigenetics in Genome Regulation. Curr Opin Solid St M. 2021, 25(1):100892. doi: 10.1016/j.cossms.2020.100892.#Corresponding author. . 



[5] Huang Z, Ouyang M., Lu S., Wang Y#Peng Q#. Optogenetic Control for Investigating Subcellular Localization of Fyn Kinase Activity in Single Live Cells. J Mol Biol. 2020, pii: S0022-2836(20)30236-9. DOI: 10.1016/j.jmb.2020.03.015.#Corresponding author. 

 

[6] Li S., Yang D., Gao L., Wang Y.#, Peng Q#. Epigenetic Regulation and Mechanobiology. Biophysics Reports2020, 6(2-3): 33-48.DOI: 10.1007/s41048-020-00106-x.#Corresponding author. 

 

[7] Peng Q., Wang Y., Qiu J., Zhang B., Sun J., Lv Y., Yang L. A Novel Mechanical Loading Model for Studying the Distributions of Strain and Mechano-growth Factor Expression. Arch Biochem Biophys. 2011, 511(1-2): 8-13. DOI: 10.1016/j.abb.2011.04.016. 

 

[8] Peng Q., Qiu J., Sun J., Yang L., Zhang B., Wang Y. The Nuclear Localization of MGF Receptor in Osteoblasts under Mechanical Stimulation. Mol Cell Biochem. 2012, 369(1-2): 147-56. DOI: 10.1007/s11010-012-1377-9. 

 

[9] MAEM. S., Safitri M., Zhou T., Wang L., McGinty S., Zhang H., Yin Y., Peng Q., Qiu J., Wang G. Unexpected Role of Nonimmune Cells: Amateur Phagocytes. DNA Cell Biol. 2021, 40(2):157-171. DOI: 10.1089/dna.2020.5647. (cover paper)

 

[10] Yang J, Zhao Z, Du C, Wang W, Peng Q, Qiu J, Wang G. The realization of robotic neurorehabilitation in clinical: use of computational intelligence and future prospects analysis. Expert Rev Med Devices. 2020, 17(12):1311-1322. DOI: 10.1080/17434440.2020.1852930.

 

[11] Dutta P., Zhang L., Zhang H., Peng Q., Montgrain P., Wang Y., Song Y., Li J., Li W. Unphosphorylated STAT3 in Heterochromatin Formation and Tumor Suppression in Lung Cancer. BMC Cancer, 2020, 20 (1), 145. 

 

[12] Ouyang M., Wan R., Qin Q., Peng Q., Wang P., Wu J., Allen M., Shi Y., Laub S., Deng L., Lu S., Wang Y. A Sensitive FRET Biosensor Reveals Fyn Kinase Regulation by Sub-membrane Localization. ACS Sensors. 2019, 4(1): pp76-86. DOI: 10.1021/acssensors.8b00896.

 

[13] Yong S., Wang P., Peng Q., Wang Y., Shuang KK. Acoustic-transfection for Genomic Manipulation of Single-cells Using High Frequency Ultrasound. Sci Rep. 2017, 7(1): 5275. DOI: 10.1038/s41598-017-05722-1. 

 

[14] Wan R., Wu J., Ouyang M., Lei L., Wei J., Peng Q., Harrison R., Wu Y., Cheng B., Li K., Zhu C., Tang L., Lu S., Wang Y. Biophysical Basis underlying Dynamic Lck Activation Visualized by ZapLck FRET Biosensor. Sci Adv. 2019, 5 (6): eaau2001. DOI: 10.1126/sciadv. aau2001. 

 

[15] Hard R., Li N., He W., Ross B., Mo GCH., Peng Q., Stein RSL., Komives E., Wang Y., Zhang J., Wang W. Deciphering and Engineering Chromodomain-Methyllysine Peptide Recognition. Sci Adv. 2018, 4(11): eaau1447. DOI: 10.1126/sciadv.aau 1447. 

 

[16] Wang P., Liang J., Shi L., Wang Y., Zhang P., Ouyang M., Preece D., Peng Q., Shao L., Fan J., Sun J., Li S., Berns M., Zhao H., Wang, Y. (2018) Visualizing spatiotemporal dynamics of intercellular mechanotransmission upon wounding, ACS Photonics. 2018, 5 (9), pp 3565–3574. DOI: 10.1021/acsphotonics.8b00383. 

 

[17] Qin Q., Laub S., Shi Y., Ouyang M., Peng Q., Zhang J., Wang Y., Lu S. Fluocell for Ratiometric and High-throughput Live-cell Image Visualization and Quantitation. Frontiers in Physics, Section Computational Physics, 2019, 7:154. DOI: 10.3389/fphy.2019.00154. 

 

[18] Liao X., Lu S., Wu Y., Xu W., Zhuo Y., Peng Q., Li B., Zhang L., Wang Y. The Effect of Differentiation Induction on FAK and Src Activity in Live HMSCs Visualized by FRET. Plos One. 2013, 8(8): e72233. DOI: 10.1371/journal.pone.0072233. 

 

[19] Qiu J., Peng Q., Zheng Y., Hu J., Luo X., Teng Y., Jiang T., Yin T., Tang C., Wang G. OxLDL Stimulates Id1 Nucleocytoplasmic Shuttling in Endothelial Cell Angiogenesis via PI3K Pathway. Biochim Biophys Acta. 2012, 1821(10): 1361-9. DOI: 10.1016/j.bbalip.2012.07.016. 



[20] Chen X., Zhang B., Wang Y., Xian C., Yang L., Deng M., Peng Q., Li Y. Mechano-growth Factor E Peptide Inhibits the Differentiation and Mineralization of Osteoblasts. Arch Oral Biol. 2012, 57(6): 720-7. DOI: 10.1016/j.archoralbio.2011.11.016. 

 

[21] Qiu J., Wang G., Zheng Y., Hu J., Peng Q., Yin T. Coordination of Id1 and p53 Activation by Oxidized LDL Regulates Endothelial Cell Proliferation and Migration. Ann Biomed Eng. 2011, 39(2): 2869-78. DOI: 10.1007/s10439-011-0382-6. 

 

[22] Qiu J., Wang G., Peng Q., Hu J., Luo X., Zheng Y., Teng Y., Tang C. Id1 Induces Tubulogenesis by Regulating Endothelial Cell Adhesion and Cytoskeletal Organization Through Beta1-integrin and Rho-kinase Signaling. Int J Mol Med. 2011, 28(4): 543-8. DOI: 10.3892/ijmm.2011.741.

 

[23] Qiu J., Wang G., Hu J., Peng Q., Zheng Y. Id1-induced Inhibition of p53 Facilitates Endothelial Cell Migration and Tube Formation by Regulating the Expression of Beta1-integrin. Mol Cell Biochem. 2011, 357(1-2): 125-33. DOI: 10.1007/s11010-011-0882-6.